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HMGB4 Rabbit Polyclonal Antibody
CAT＃: TA322036S
Anti-HMGB4 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 3,080.00
Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB: 200-1000 WB positive control: 231 cells and human fetal liver tissue |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Full length fusion protein |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 22 kDa |
| Gene Name | high mobility group box 4 |
| Database Link | |
| Background | High mobility group protein B4?is a?transcription factor?that in humans is encoded by the?HMGB4?gene.HMGB4 is strongly and preferentially expressed in the adult mouse testis and weakly in the brain; but not in many other tissues. HMGB4 associates with chromatin; and in transfection assays; in contrast to HMGB1; it acts as a potent transcriptional repressor. During spermatogenesis; HMGB4 is present in the euchromatin of late pachytene spermatocytes and haploid round spermatids; whereas stronger expression is observed during the elongation phase; where it localizes to the basal pole of the nucleus in a manner mutually exclusive with H1FNT (H1T2) localized at the apical pole. HMGB4 basal localization is lost in H1FNT-mutant spermatids; showing that H1FNT provides a positional cue for organizing chromatin domains within the nucleus. These results show that HMGB4 and H1FNT specify distinct chromatin domains at the apical and basal poles of the elongating spermatid nucleus. |
| Synonyms | dJ1007G16.5 |
| Reference Data | |
| Protein Families | Transcription Factors |
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