SCN11A Rabbit Polyclonal Antibody
CAT#: TA322396
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Anti-SCN11A Rabbit Polyclonal Antibody
Size: 25 ul
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CN¥ 1,999.00
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Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 50-200 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 29-41 amino acids of human sodium channel, voltage-gated, type XI, alpha subunit |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | sodium voltage-gated channel alpha subunit 11 |
Database Link | |
Background | Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits; such as SCN11A; mediate voltage-dependent gating and conductance; while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers. |
Synonyms | FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A; SNS-2 |
Reference Data | |
Protein Families | Druggable Genome, Ion Channels: Sodium, Transmembrane |
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