CEBP Alpha (CEBPA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-100 Positive control: Human tonsil Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 82-100 amino acids of Human CCAAT/enhancer binding protein (C/EBP), alpha
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CCAAT/enhancer binding protein alpha
Database Link	NP_004355 Entrez Gene 12606 MouseEntrez Gene 24252 RatEntrez Gene 1050 Human UniProt ID P49715
Background	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin; a protein that plays an important role in body weight homeostasis. Also; the encoded protein can interact with CDK2 and CDK4; thereby inhibiting these kinases and causing growth arrest in cultured cells.
Synonyms	C; CEBP; EBP-alpha
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways	Acute myeloid leukemia, Pathways in cancer

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