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Securin (PTTG1) Rabbit Polyclonal Antibody
CAT＃: TA322777S
Anti-PTTG1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 99-112 amino acids of human |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | pituitary tumor-transforming 1 |
| Database Link | |
| Background | The encoded protein is a homolog of yeast securin proteins; which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo; and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs; which are required for its transforming and tumorigenic activities; as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein; although it partially localizes in the nucleus. |
| Synonyms | EAP1; HPTTG; PTTG; TUTR1 |
| Reference Data | |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Cell cycle, Oocyte meiosis |
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