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DTX2 Rabbit Polyclonal Antibody
CAT＃: TA323238S
Anti-DTX2 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 4,840.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 50-100 Positive control: Human brain Predicted cell location: Cytoplasm and Nucleus |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to C terminal 300 amino acids of human deltex homolog 2 (Drosophila) |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | deltex 2, E3 ubiquitin ligase |
| Database Link | |
| Background | DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling; a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch; depending on the developmental and cell context. Mediates the antineural activity of Notch; possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro; suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
| Synonyms | RNF58 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Notch signaling pathway |
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