Sonic Hedgehog (SHH) Rabbit Polyclonal Antibody

CAT#: TA323716

Anti-SHH Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

Product images

经常一起买 (4)
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Recombinant protein of human sonic hedgehog homolog (Drosophila) (SHH), 20 µg
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Recombinant protein of human sonic hedgehog homolog (Drosophila) (SHH), 100 µg
    • 100 ug

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Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 50-100
Positive control: Human breast cancer
Predicted cell location: Cytoplasm, ExtraCellular space
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 448-462 amino acids of Human sonic hedgehog
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name sonic hedgehog
Background This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube; the anterior-posterior limb axis; and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila; this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly; the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product; restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE); a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome; which is characterized by vertebral defects; anal atresia; tracheoesophageal fistula with esophageal atresia; radial and renal dysplasia; cardiac anomalies; and limb abnormalities. Additionally; mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
Synonyms HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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