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Growth hormone receptor (GHR) Rabbit Polyclonal Antibody
CAT＃: TA323722S
Anti-GHR Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB: 200-1000 WB positive control: PC cell |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 48-63 amino acids of Human growth hormone receptor |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 69 kDa |
| Gene Name | growth hormone receptor |
| Database Link | |
| Background | This gene encodes a member of the type I cytokine receptor family; which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome; also known as the growth hormone insensitivity syndrome (GHIS); a disorder characterized by short stature. In humans and rabbits; but not rodents; growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
| Synonyms | GHBP; GHIP |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Neuroactive ligand-receptor interaction |
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