TOP1MT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 151-165 amino acids of human topoisomerase (DNA) I, mitochondrial
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	topoisomerase (DNA) I, mitochondrial
Database Link	NP_443195 Entrez Gene 116447 Human UniProt ID Q969P6
Background	This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms	2900052H09Rik; mitochondrial; mitochondrial topoisomerase I; topoisomerase (DNA) I
Reference Data
Protein Families	Druggable Genome

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