ERp57 (PDIA3) Mouse Monoclonal Antibody [Clone ID: Map.ERP57]

Specifications

Product Data
Clone Name	Map.ERP57
Applications	WB
Recommend Dilution	WB: 1:2000
Reactivity	Human, Mouse, Bovine, Canine, Monkey, Pig, Rabbit, Rat, Hamster, Guinea Pig
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Recombinant Erp57 (Grp58)
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	protein disulfide isomerase family A member 3
Database Link	NP_005304 Entrez Gene 14827 MouseEntrez Gene 29468 RatEntrez Gene 711029 MonkeyEntrez Gene 2923 Human UniProt ID P30101
Background	ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs . It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface . ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus .
Synonyms	ER60; ERp57; ERp60; ERp61; GRP57; GRP58; HEL-S-93n; HEL-S-269; HsT17083; P58; PI-PLC
Note	Detects ~57kDa.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Antigen processing and presentation

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