Hsp40 (DNAJB1) Rabbit Polyclonal Antibody [Clone ID: N/A]

Specifications

Product Data
Clone Name	N/A
Applications	WB
Recommend Dilution	WB: 1:1500-2000
Reactivity	Human, Mouse, Rat, African Green Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant purified human hsp40
Formulation	Rabbit antiserum
Concentration	lot specific
Purification	Rabbit antiserum
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	DnaJ heat shock protein family (Hsp40) member B1
Database Link	NP_006136 Entrez Gene 81489 MouseEntrez Gene 361384 RatEntrez Gene 718890 MonkeyEntrez Gene 3337 Human UniProt ID P25685
Background	DnaJ/Hsp40 proteins have been preserved throughout evolution and are important for protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of chaperone proteins, Hsp70s. Because the ATP hydrolysis is essential for the activity of Hsp70s, DnaJ/Hsp40 proteins actually determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. DnaJ/Hsp40 proteins all contain the J domain through which they bind to Hsp70s. Hsp40, also known as HDJ1 , is a basic mammalian 40kDa heat shock protein which is not only homologous to the bacterial heat shock protein (DnaJ), but also yeast DnaJ-related proteins such as SCJ1, Sec63/Npl1, YDJ1 and SIS1 . Hsp 40 is inducible by stress including heat after which is moves from the cytoplasm to the nucleus and nucleoli; an intracellular pattern similar to Hsc70/Hsp70, the mammalian homologues of the bacterial heat shock protein, DnaK .
Synonyms	Hdj1; Hsp40; HSPF1; RSPH16B; Sis1
Note	Detects an ~40kDa protein corresponding to the molecular mass of Hsp40 on SDS PAGE immunoblots. Also detects recombinant Hsp40.
Reference Data

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