PSD95 (DLG4) Mouse Monoclonal Antibody [Clone ID: S28-43]

Specifications

Product Data
Clone Name	S28-43
Applications	IF, IHC
Recommend Dilution	WB: 1:1000
Reactivity	Mouse, Rat, Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 77-200 of human PSD95/SAP90
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	discs large MAGUK scaffold protein 4
Database Link	NP_001356 Entrez Gene 13385 MouseEntrez Gene 29495 RatEntrez Gene 1742 Human UniProt ID P78352
Background	Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds toneuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
Synonyms	PSD95; SAP-90; SAP90
Note	Detects ~95-110kDa.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease

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