GRP94 (HSP90B1) Rabbit Polyclonal Antibody

CAT#: TA326478

Rabbit Polyclonal Anti-Grp94 Antibody



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CNY 5,379.00


货期*
4周

规格
    • 100 ug

Product images

经常一起买 (4)
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Recombinant protein of human heat shock protein 90kDa beta (Grp94), member 1 (HSP90B1), 20 µg
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Recombinant protein of human heat shock protein 90kDa beta (Grp94), member 1 (HSP90B1), 100 µg
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Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:1000, IP: 1:80
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to the sequence near the C-terminus of mouse GRP94.
Formulation PBS pH 7.4, 0.09% azide.
Concentration lot specific
Purification Peptide Affinity Purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name heat shock protein 90kDa beta family member 1
Background Grp94 (glucose regulated protein 94, gp96) is a constitutively expressed endoplasmic reticulum (ER) lumenal protein that is up-regulated in response to cellular stress such as heat shock, oxidative stress or glucose depletion. Grp94 is thought to play a role in protein translocation to the ER, in their subsequent folding and assembly, and in regulating protein secretion . Grp94 also plays a role in antigen presentation by accessing the endogenous pathway and eliciting specific CTL responses to chaperone bound peptides via MHC class I pathway Grp94 is a member of the Hsp90 family of stress proteins and shares sequence homology with its cytosolic equivalent, Hsp90 . Both Hsp90 and Grp94 are calcium binding proteins . Despite sharing 50% sequence homology over its N domains and complete conservation in its ligand binding domains with Hsp90, Grp94 and Hsp90 differ in their interactions with regulatory ligands as Grp94 has weak ATP binding and hydrolyisis activity .Grp94 exists as a homodimer and the two subunits interact at two distinct intermolecular sites, C terminal dimerization domains and the N-terminal interacts with the middle domain of opposing subunits. . Grp94 contains a carboxy terminal KDEL (Lys-Asp-Glu-Leu) sequence which is believed to aid in its retention in the ER .
Synonyms ECGP; GP96; GRP94; HEL-S-125m; HEL35; TRA1
Note Detects ~94kDa.
Reference Data
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway, Pathways in cancer, Prostate cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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