Noelin (OLFM1) Mouse Monoclonal Antibody [Clone ID: S96-7]

Specifications

Product Data
Clone Name	S96-7
Applications	IHC
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide of amino acids 28-48 of human pancortin-1 (SLVGLNTTRLSAASGGTLDRS)
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	olfactomedin 1
Database Link	NP_055094 Entrez Gene 56177 MouseEntrez Gene 93667 RatEntrez Gene 10439 Human UniProt ID Q99784
Background	Pancortin, a member of a diverse family of secreted glycoproteins, is implicated in the development of the nervous system, and the glaucoma-associated protein myocilin . Studies suggest that Pancortin-2 interact with WAVE1 in a novel cell death cascade in adult, but not embryonic, cerebral cortical neurons. Specifically pancortin-2 is a mediator of ischemia-induced apoptosis of neurons in the adult cerebral cortex, and functions in a novel mitrochondrial/actin associated protein complex that sequesters Bcl-xL . It is also involved in the generation of neural crest cells, and in neurogenesis .
Synonyms	AMY; NOE1; NOELIN1; OlfA
Note	Detects ~70kDa (Pancortin-1, Pancortin-3) and ~20kDa (Pancortin-2 and Pancortin-4).
Reference Data
Protein Families	Druggable Genome

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