Scn2a Mouse Monoclonal Antibody [Clone ID: S69-3]

Specifications

Product Data
Clone Name	S69-3
Applications	IHC, WB
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat Nav1.2
Formulation	PBS pH7.4, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sodium voltage-gated channel alpha subunit 2
Database Link	NP_036779 Entrez Gene 6326 HumanEntrez Gene 110876 MouseEntrez Gene 24766 Rat UniProt ID P04775
Background	Nav1.2 is a protein that in humans is encoded by the SCN2A gene. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane doains and one or moreregulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle . Neuronal Nav1.2 channels are therapeutic targets in seizure, pain and stroke .
Synonyms	BFIC3; HBA; HBSCI; HBSCII; Na(v)1.2; NAC2; Nav1.2; OTTHUMP00000041050; SCN2A1; SCN2A2
Note	Detects ~250kDa.
Reference Data

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