PPAR gamma (PPARG) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC
Recommend Dilution	IF 1:50 - 1:100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	N term -peptide of human PPARG
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	peroxisome proliferator activated receptor gamma
Database Link	NP_005028 Entrez Gene 19016 MouseEntrez Gene 25664 RatEntrez Gene 5468 Human UniProt ID P37231
Background	Peroxisome proliferator-activated receptor ? (PPAR?) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator (1). PPAR? is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage (2). Besides its role in mediating adipogenesis and lipid metabolism (2), PPAR? also modulates insulin sensitivity, cell proliferation and inflammation (3). PPAR? transcriptional activity is inhibited by MAP kinase phosphorylation of PPAR? at Ser84 (4,5).1. Tontonoz, P. et al. (1995) Curr. Opin. Genet. Dev. 5, 571-576.2. Rosen, E.D. et al. (1999) Mol. Cell 4, 611-617.3. Murphy, G.J. and Holder, J.C. (2000) Trends Pharmacol. Sci. 21, 469-474.4. Camp, H.S. and Tafuri, S.R. (1997) J. Biol. Chem. 272, 10811-10816.5. Adams, M. et al. (1997) J. Biol. Chem. 272, 5128-5132.
Synonyms	CIMT1; GLM1; NR1C3; PPARG1; PPARG2; PPARgamma
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways	Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer

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