IL1 alpha (IL1A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human IL1A
Formulation	PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 1 alpha
Database Link	NP_000566 Entrez Gene 3552 Human UniProt ID P01583
Background	IL-1a is a pro-inflammatory cytokine produced by activated monocytes, lymphocytes and epithelial cells. IL-1a is synthesized as an active precursor protein that appears to be cleaved by cytosolic proteases into its mature form . Often, precursor and mature forms of IL-1a are primarily retained intracellularly rather than constitutively secreted. . Signaling by IL-1a involves IL-1a binding to an IL-1 accessory protein (IL-1-AcP) and then the complex binds to IL-1RI . Signaling is through activation of MAP kinase and NF?B pathways . IL-1a also binds to an IL-RII that lacks an intracellular signaling domain and thereby serves as a high affinity decoy receptor. Inhibition of IL-1a activity is through IL-1R antagonist (IL-1Ra) that binds IL-1R1 but does not signal. IL-1a has been shown to be a key mediator of virus-induced inflammatory responses in mice .
Synonyms	IL-1A; IL1; IL1-ALPHA; IL1F1
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, Prion diseases, Type I diabetes mellitus

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