AP2M1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human AP2M1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	adaptor related protein complex 2 mu 1 subunit
Database Link	NP_004059 Entrez Gene 1173 Human UniProt ID Q96CW1
Background	The AP-2 coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane. Each AP-2 heterotetramer is composed of a, β, µ, and s protein subunits. The 50 kDa µ subunit (AP-2µ, AP2M1) is located at the core of the AP-2 complex and mediates interaction between the cargo protein and the clathrin-coated pit. The carboxy-terminal AP2M1 region recognizes the tyrosine-based, endocytotic sorting motif YXXf found in cargo proteins and helps to bring the cargo protein to the clathrin-coated pit. Non-canonical, tyrosine-based endocytotic sorting signals can also promote interaction between cargo proteins and AP2M1. AP2M1 plays an essential role in molecular signaling as it couples receptor-mediated endocytosis and pathways involving membrane receptors, matrix metalloproteinases, and ion channel proteins. Phosphorylation of specific AP2M1 residues and binding of lipids to this adaptor protein can regulate AP2M1 activity. Phosphorylation of AP2M1 at Thr156 by adaptor-associated kinase 1 (AAK1) stimulates affinity binding of AP2M1 to cargo protein signals.
Synonyms	AP50; CLAPM1; mu2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis, Huntington's disease

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