Histone H2A.X (H2AFX) Mouse Monoclonal Antibody [Clone ID: 2F3]

Specifications

Product Data
Clone Name	2F3
Applications	IF, WB
Recommend Dilution	WB, IHC, ICFC, IF
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Modified peptide
Formulation	This H2A.X antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Final antibody concentration is 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	14 kD
Gene Name	H2A histone family member X
Database Link	NP_002096 Entrez Gene 15270 MouseEntrez Gene 3014 Human UniProt ID P16104
Background	H2A.X is a 14 kD basal histone and a member of the H2 histone family. This nuclear protein is synthesized in the G1 and S phase of the cell cycle and is known to be important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 after double-stranded DNA breaks. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability. The 2F3 monoclonal antibody reacts with phosphorylated human H2A.X (Ser139) and has been shown to be useful for Western blotting and immunofluorescence.
Synonyms	H2A; H2A.X; H2AX; X
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Systemic lupus erythematosus

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