Eg5 (KIF11) Mouse Monoclonal Antibody [Clone ID: 10C7/Eg5]

Specifications

Product Data
Clone Name	10C7/Eg5
Applications	WB
Recommend Dilution	WB, IP, IF
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Amino Acid: 200-500 of human Eg5
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	119 kD
Gene Name	kinesin family member 11
Database Link	NP_004514 Entrez Gene 16551 MouseEntrez Gene 3832 Human UniProt ID P52732
Background	Eg5 (also known as kinesin-like protein KIF11, kinesin-related motor protein Eg5, kinesin-like spindle protein HKSP, and thyroid receptor interacting protein 5 (TRIP5)) is a 119 kD kinesin-like protein family, BimC subfamily. This protein is a catalytic kinesin motor with coiled-coil and Smc domains. Eg5 is localized at the centrosomes, spindle microtubules, and intracellular bridge. This motor protein is required for establishing the bipolar spindle. hEg5 is modified by phosphorylation on Thr927 by Cdc2 to allow association with the spindle apparatus. Eg5 has been shown to interact with the thyroid hormone receptor in presence of thyroid hormone and Cdc2. The 10C7/Eg5 monoclonal antibody has been shown to react with human and mouse Eg5 by Western blot.
Synonyms	EG5; HKSP; KNSL1; MCLMR; TRIP5
Reference Data
Protein Families	Druggable Genome

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