Leukotriene B4 Receptor (LTB4R) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3,000; FC: 1:50-1:600
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide CFPRYPSEGHRAFH, corresponding to amino acid residues 168-181 of human BLT1. 2nd extracellular loop.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	leukotriene B4 receptor
Database Link	NP_858043 Entrez Gene 1241 Human UniProt ID Q15722
Background	Leukotrienes (LTs) are lipid mediators prominently exerting proinflammatory responses. They are divided in two classes: cysteinyl LTs (cysLTs) which have a thioester linkage and LTB4. LTB4, a chemoattractant plays a prominent role in the recruitment and activation of leukocytes. LTB4 acts through two receptors which belong to the G-protein coupled receptor superfamily: BLT1 and BLT2. BLT1 displays high affinity for LTB4 and is highly expressed in leukocytes including granulocytes, macrophages, mast cells, dendritic cells and effector T cells and is expressed to much lower levels in spleen, thymus, heart, skeletal muscle brain and liver. BLT2 on the other hand is a low affinity receptor which does not display selectivity towards LTB4. Its expression is much more ubiquitous than that of BLT1. It is expressed in most human tissues, with the highest expression being in spleen, liver, ovary, and leukocytes. The two receptors could couple and activate different G-proteins, depending on the cell type and the cellular events activating the receptors. However, activation of BLT1 ususally correlates with increasing intracellular concentrations of Ca2+. The LTB4/BLT1 system is involved in many allergic reactions as well as asthma induced as an allergic response, where it plays a significant role in recruiting neutrophils and effector T cells into lungs, as part of an inflammatory response induced by allergens.
Synonyms	BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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