Neurotrophin 4 (NTF4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide LGEVPAAGGSPL(C), corresponding to amino acid residues 43-52 of mature human NT-4Â (123-132 of the precursor NT-4).
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 5% sucrose, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	neurotrophin 4
Database Link	NP_006170 Entrez Gene 4909 Human UniProt ID P34130
Background	The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS. Neurotrophin-4 (NT-4) is expressed in neurons of the superior cervical, stellate and celiac ganglion, T-cells and is synthesized by keratinocytes. The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as PDGF. The rat and human forms of NT-4 are 96% homologous. NT-4 has been shown to promote dendritic outgrowth and calcium currents in cultured mesencephalic dopamine neurons, to promote growth and remodeling of adult motor neuron innervation, to be anterograde survival factors for postsynaptic cells and to protect against apoptotic neuronal death. The biological effects of NT-4 are mediated by two receptors: TrkB, which is specific for NT-4 and BDNF, and p75 which binds all the neurotrophins.
Synonyms	5; GLC1O; GLC10; NT-4; NT-5; NT4; NT5; NTF5
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	MAPK signaling pathway, Neurotrophin signaling pathway

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