Nav1.5 (SCN5A) Rabbit Polyclonal Antibody

CAT#: TA328703

Rabbit Polyclonal Anti-Human NaV1.5



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CNY 11,000.00


货期*
4周

规格
    • 50 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1:200-1:2000; IHC: 1:100-1:3,000; FC: 1:50-1:600
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Immunogen GST fusion protein with amino acid residues 1978-2016 of human Nav1.5. Intracellular, C-terminus.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then anti-Nav1.5 antibody was affinity purified on immobilized Nav1.51978-2016.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name sodium voltage-gated channel alpha subunit 5
Background Voltage-gated Na+ channels (Nav) are responsible for myocardial conduction and maintenance of the cardiac rhythm and are essential for the generation of action potentials and cell excitability. Dysfunction or disregulation of cardiac sodium channels can cause several disorders, including cardiac arrhythmias. The majority of Na+ channels in the mammalian heart are Tetrodotoxin (TTX) insensitive Nav1.5. The putative structure of NaV1.5 consists of four homologous domain (I-IV), each containing six transmembrane segments (S1-S6). Mutations in the C-terminus of NaV1.5 were described in connection to Long QT syndrome and Brugada syndrome. Recent data have demonstrated selective expression of NaV1.5 in the mouse central nervous system and implicated a role for NaV1.5 in the physiology of the central nervous system.
Synonyms CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1
Reference Data
Protein Families Druggable Genome, Ion Channels: Sodium, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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