alpha 1a Adrenergic Receptor (ADRA1A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide EDETI*SQINEEPG(C), corresponding to amino acid residues 171-183 of human a1A adrenoceptor with replacement of cysteine 176 (C176) with serine. 2nd extracellular loop.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	adrenoceptor alpha 1A
Database Link	NP_150645 Entrez Gene 29412 RatEntrez Gene 148 Human UniProt ID P35348
Background	Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus. The Adrenoceptors are divided into three types: a1, a2 and Ã? adrenoceptors. Each type is further divided into at least three subtypes:a1A, a1B, a1D, a2A, a2B, a2C, Ã?1, Ã?2, Ã?3.They are expressed in nearly all peripheral tissues and in the central nervous system. All a1-Adrenoceptors (a1-ARs) activate phospholipases C and A2. In addition to mobilizing intracellular calcium, the a1-ARs have also been shown to activate calcium influx via voltage-dependent and independent calcium channels. The a1A-ARs have at least nine known alternative spliced isoforms. They are the most abundant adrenergic receptor in the brain, and considered postsynaptic receptors. a1A-ARs are also expressed in heart, liver and prostate.
Synonyms	ADRA1C; ADRA1L1; ALPHA1AAR
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.