Adrb3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide DAEAQESH*SNPRC, corresponding to amino acid residues 180-192 of mouse Ã?3-Adrenoceptor with replacement of cysteine 186 (C186) with serine (*S). 2nd extracellular loop.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	adrenergic receptor, beta 3
Database Link	NP_038490 Entrez Gene 25645 RatEntrez Gene 11556 Mouse UniProt ID P25962
Background	Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: a1, a2 and Ã?-Adrenoceptors. Each type is further divided into at least three subtypes: a1A, a1B, a1D, a2A, a2B, a2C, Ã?1, Ã?2, Ã?3. The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system. The Ã?3-Adrenoceptor is insensitive to the commonly used Ã?-antagonists and has often been referred to as the 'atypical' Ã?-Adrenoceptor. Mouse Ã?3-Adrenoceptor has two known splice variants, isoforms Ã?3a-Adrenoceptor and Ã?3b-Adrenoceptor. Both isoforms are expressed in white and brown adipose tissues. The Ã?3b-Adrenoceptor is highly exspressed in brain. The Ã?3- Adrenoceptor has been found to play a key role in the lipolytic action of catecholamines.
Synonyms	ADRB3R; B3AR; BETA3AR; FLJ99960
Reference Data

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