Cacnb2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)HEHVDRYVPHREHNHRE, corresponding to amino acid residues 571-587 of rat CavÃ?2. Intracellular, C-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calcium voltage-gated channel auxiliary subunit beta 2
Database Link	NP_446303 Entrez Gene 12296 MouseEntrez Gene 116600 Rat UniProt ID Q8VGC3
Background	Voltage-dependent Ca2+ channels are a family of membrane proteins that allow cells to couple electrical activity to intracellular Ca2+ signaling. Voltage-gated Ca2+ channels are classified as T, L, N, P, Q and R, and are distinguished by their sensitivity to pharmacological blocks, single-channel conductance kinetics, and voltage-dependence.On the basis of their voltage activation properties, voltage-gated Ca2+ subtypes can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels. The activity of the channel pore is modulated by 4 tightly-coupled subunits: an intracellular Ã? subunit; a transmembrane ? subunit; and a disulphide-linked complex of a2 and d subunits. There are four distinct Ã? subunits: Ã?1, Ã?2, Ã?3 and Ã?4. There are 4 splice variants of the Ã?2 subunit: Ã?2a, Ã?2b, Ã?2c and Ã?2d. Ã?2a and Ã?2b are expressed in heart, aorta and brain, and are 606- and 632-residue proteins, respectively. Ã?2c and Ã?2d (655 and 604 residues, respectively) are expressed in brain, and recent studies show beta-2c to be also expressed in heart. All splice variants differ in their N-terminal regions.
Synonyms	CAB2; CACNLB2; CAVB2; FLJ23743; MYSB
Reference Data

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