Kcnk10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide TFRNYSLDEEKKEDETEKMC, corresponding to amino acid residues 475-494 of rat K2P10.1 . Intracellular, C-terminal domain.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium two pore domain channel subfamily K member 10
Database Link	NP_075584 Entrez Gene 54207 HumanEntrez Gene 65272 Rat UniProt ID Q9JIS4
Background	K2P10.1 is a member of the 2-pore (2P) domain K+ channels. These K+ channels also also known as background or “leak” channels and help to set the resting membrane potential. K2P channels can be activated by a wide variety of stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. The channels can also be subclassified based on their specific activators. K2P10.1 can be integrated to a K2P subfamily which includes K2P2.1 (TREK1) and K2P4.1 (TRAAK) that are activated by intracellular unsaturated fatty acids such as arachidonic acid, low intracellular pH and mechanical stretch. K2P10.1 mRNA expression has been detected in the brain (primarily in the cerebellum) and in peripheral tissues such as pancreas and kidney.
Synonyms	FLJ43399; K2p10.1; TREK-2; TREK2
Reference Data

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