Kcna7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide TTRKAQEIHGKAPG(C), corresponding to amino acid residues 2-15 of mouse KV1.7. Intracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel, shaker-related subfamily, member 7
Database Link	NP_034726 Entrez Gene 16495 Mouse UniProt ID Q17ST2
Background	The Kv1.7 voltage-gated K+ channel, is a member of the Shaker family of K+ channels that today includes eight members (Kv1.1- Kv1.8). Kv1.7 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains and intracellular N and C termini. As with other channels of the Shaker subfamily, Kv1.7 can readily form heteromers with other members of the subfamily to compose the tetramer that forms the functional channel.Kv1.7 mRNA was found to be expressed mainly in the heart with somewhat lower levels in pancreas and skeletal muscle.The biophysical and pharmacological properties of the Kv1.7 channel closely resembles that of the ultra-rapidly activating delayed rectifier (IKur) in cardiac tissue. This current plays a central role in cardiac atrial repolarization that was largely believed to correspond to the activity of the Kv1.5 channel. This raises the possibility that the IKur current is the result of a heteromeric Kv1.5/ Kv1.7 channel.
Synonyms	HAK6; Kv1.7
Reference Data

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