Kcnh4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide CRLNQEISRLNQEVS, corresponding to amino acids 881-895 of rat Kv12.3 . Intracellular, C-terminal part.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel subfamily H member 4
Database Link	NP_446082 Entrez Gene 23415 HumanEntrez Gene 114032 Rat UniProt ID Q9R1T9
Background	Kv12.3 (also known as elk3 and KCNH4) is a voltage-gated K+ channel that belongs to the ether-a-go-go (EAG) family. The EAG family of voltage-gated K+ channels can be subdivided into three distinct groups based on sequence homology. These are the eag (Kv10) with two members, the eag-related channels (erg or Kv11) and the eag-like K+ channels (elk or Kv12) with three members each.As all members of the family, Kv12.3 possesses the signature structure of the voltage-dependent K+ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K+ channels the functional channel is a tetramer composed of four subunits. It has been suggested that the Kv12 subfamily members can form functional heteromultimers within the subfamily.Kv12.3 channel distribution appears to be mainly confined to the central nervous system with some expression in peripheral organs such as testis and lung. The physiological function of the Kv12.3 channel hasnâ??t been established, although a role in the modulation of overall excitability of neurons has been suggested. At the moment there isnâ??t much pharmacological data concerning the modulation of the Kv12.3 channel except for blocking of the channel by Ba2+.
Synonyms	BEC2; elk1; Kv12.3
Reference Data

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