Kcnab2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide SPGMIYSTRYGSPKR(C), corresponding to amino acid residues 20-34 of rat KvÃ?2 . N-terminal part.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel subfamily A regulatory beta subunit 2
Database Link	NP_059000 Entrez Gene 8514 HumanEntrez Gene 16498 MouseEntrez Gene 29738 Rat UniProt ID P62483
Background	KvÃ?2 (or KCNAB2) is a member of a family of proteins that regulate the activity of voltage-dependent K+ channels. The other members of the family are KvÃ?1 and KvÃ?3.The KvÃ? subunits were originally identified using a biochemical approach that demonstrated that the ion-conducting a subunits existed in a macromolecular complex with auxiliary Ã? subunits with a probable stoichiometry of a4Ã?4. It is now widely established that the regulatory Ã? subunits are able to alter both the biophysical (i.e. acceleration of inactivation kinetics) and biochemical (promote cell surface expression) properties of the functional Kv channel.The KvÃ? regulatory subunits are cytosolic proteins with conserved C-termini and variable N-terminus domains. The interaction with the a subunits is via the conserved C-terminal end that binds to a specific sequence in the N-terminus domain of the a subunits.KvÃ?2, as well as the other KvÃ? subunits can bind to all the members of the large Kv1.x (Shaker) channel subfamily. However, recent evidence suggests that it can also bind to members of the Kv4.x subfamily.KvÃ?2 is the most abundant Ã? subunit in the brain where it couples with all the Kv1.x subunits, but the protein is also expressed in peripheral tissues including heart, lung and cells of hematopoietic origin such as T cells where it couples with Kv1.3, the dominant voltage-dependent K+ channel in these cells. We have now developed a highly specific antibody directed against a unique region in the N-terminus end of the rat KvÃ?2 protein. The antibody will also recognize KvÃ?2 samples from mouse and human origin.
Synonyms	AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KCNK2; KV-BETA-2; MGC117289; OTTHUMP00000000874; OTTHUMP00000000875; OTTHUMP00000000877
Reference Data

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