Kcnf1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:200-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)K(S)VWKFLEKPESS, corresponding to amino acid residues 166- 178 of mouse KV5.1 . Intracellular, N-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	potassium voltage-gated channel, subfamily F, member 1
Database Link	NP_963289 Entrez Gene 3754 HumanEntrez Gene 298908 RatEntrez Gene 382571 Mouse UniProt ID Q7TSH7
Background	Voltage-gated K+ channels are involved in maintaining membrane potential and regulating cell volume. They are also important for determining the cellular response to the external stimulus of neurotransmitters and neuro-peptides1. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.Voltage-gated K+ channels are transmembrane proteins consisting of four a-subunits arranged in radially symmetric fashion around a central aqueous pore. Each a-subunit consists of six transmembrane segments (S1â??S6) with cytoplasmic NH2- and COOH-termini 2. In mammals, a large family of genes encodes a-subunits: KV1 (homologous to Drosophila Shaker), KV2 (Shab), KV3 (Shaw), KV4 (Shal), KV5, KV6, and KV8 .New electrically silent a subunits have recently been cloned which constitute three new subfamilies: KV5.1, KV6.1, and KV8.1. These a subunits, although cannot generate K+ channel activity by themselves, can modulate in a specific way the function of KV2.1 and KV2.2 subunits. They inhibit the KV2.1 and KV2.2 channels when expressed at high concentrations.KV5.1 is expressed in heart, skeletal muscle, brain, kidney, and pancreas. A recent study revealed the expression of KV5.1 in isolated urinary bladder smooth muscle (UBSM) myocytes.
Synonyms	IK8; KCNF; kH1; KV5.1; MGC33316
Reference Data

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