Nalcn Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide (C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat Sodium leak channel non-selective protein. Extracellular, S1-S2 domain III.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sodium leak channel, non-selective
Database Link	NP_705894 Entrez Gene 259232 HumanEntrez Gene 338370 MouseEntrez Gene 266760 Rat UniProt ID Q6Q760
Background	The existence of resting K+ conductance has been known for some time. Only recently has the Nalcn (sodium leak channel non-selective protein) has been found responsible for the resting Na+ conductance. Nalcn is a member of the NaV and CaV channels family which have four homologous repeats of six transmembrane domains. One structural difference is that Nalcn is less positively charged in the voltage sensing segment. The protein forms voltage-independent non-inactivating channel which is permeable to Na+, K+ and Ca2+ ions. Evidence suggests that Nalcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die with 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability. The channel is extensively expressed in the central nervous system, heart, pituitary and adrenal glands and pancreatic islet cells. In pancreatic islets, Nalcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake.
Synonyms	bA430M15.1; CanIon; FLJ23913; FLJ44659; FLJ44764; MGC74524; VGCNL1
Reference Data

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