LIMPII (SCARB2) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.01-0.03ug/ml
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	C Terminus (TSAPKGSVLQEAK)
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	scavenger receptor class B member 2
Database Link	NP_005497 Entrez Gene 950 Human UniProt ID Q14108
Background	Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus. At least two isoforms of SCARB1 are known to exist.
Synonyms	AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII
Note	This antibody is expected to recognize isoform 1 (NP_005496.4) only.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Lysosome

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