H4C14 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, ChIP-seq, ICC/IF, IHC, IP, WB
Recommend Dilution	WB 1:500 - 1:2000;IF 1:50 - 1:200;IP 1:50 - 1:200;ChIP 1:20 - 1:100
Reactivity	Human, Mouse, Rat, Other (Wide Range)
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic methylated peptide corresponding to residues surrounding K20 of human histone H4
Formulation	PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	11 kDa
Gene Name	histone cluster 2, H4a
Database Link	NP_003539 Entrez Gene 502913 RatEntrez Gene 8370 Human UniProt ID P62805
Background	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
Synonyms	FO108; H4; H4F2; H4FN; HIST2H4; n
Reference Data
Protein Pathways	Systemic lupus erythematosus

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