Caspase-6 (CASP6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, IP, WB
Recommend Dilution	Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation: 1:50-1:200, Western Blot: 1:1000-1:2000, Immunohistochemistry-Paraffin: 1:1000-1:5000, Immunohistochemistry-Frozen
Reactivity	Human, Mouse, Rat, Canine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant catalytically active human Caspase-6 protein was used as immunogen.
Formulation	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Whole antisera
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 6
Database Link	NP_001217 Entrez Gene 12368 MouseEntrez Gene 83584 RatEntrez Gene 839 Human UniProt ID P55212
Background	Caspases belong to the cysteine-aspartic acid protease (Caspase) family which plays a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells, and are activated in response to distinct apoptosis-inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase-6 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.
Synonyms	MCH2
Note	Immunohistochemistry (frozen): Users should optimize according to model and immunodetection system used (secondary reagents) Immunocytochemistry/Immunofluorescence was reported in scientific literature.
Reference Data
Protein Families	Druggable Genome, Protease, Stem cell - Pluripotency
Protein Pathways	Apoptosis

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.