TIM 3 (HAVCR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1-3 ug/ml
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A portion of amino acids 100-200 of mouse TIM-3 protein were used as the immunogen.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	hepatitis A virus cellular receptor 2
Database Link	NP_116171 Entrez Gene 171285 Mouse UniProt ID Q8TDQ0
Background	Official Gene Symbol HAVCR2 Gene ID 84868(Human) Gene Map Locus 5q33.3(Human) HAVCR2 is a 281 A.A Type-1 Th1 specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-region like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 regulates macrophage activation thereby down regulating aggressive Th-1 mediated immune responses and facilitates in the development of immune tolerance. It plays an important role in the induction of autoimmune diseases by regulating macrophage activation. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.
Synonyms	CD366; HAVcr-2; KIM-3; Tim-3; TIM3; TIMD-3; TIMD3
Reference Data
Protein Families	Druggable Genome, Transmembrane

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