FOXP3 Mouse Monoclonal Antibody [Clone ID: 3G3]

Specifications

Product Data
Clone Name	3G3
Applications	FC, WB
Recommend Dilution	Western Blot: 2 - 5 ug/mL, Flow Cytometry: 100 ng/ 10^6 cells in 50 uL
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full-length His-tagged murine FOXP3 was used as the immunogen. The precise epitope is not known, but it has been mapped to the N-terminal portion of the protein (NP_001107849).
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at -20C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47 kDa
Gene Name	forkhead box P3
Database Link	NP_054728 Entrez Gene 20371 MouseEntrez Gene 50943 Human UniProt ID Q9BZS1
Background	One of the many immunotolerance mechanisms that the immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. Several elegant experiments using transgenic mice and retrovirus-mediated over expression studies, have led to the identification of FoxP3, a transcription factor, as a specific molecular marker essential for the development and function of Tregs. The primary evidence regarding the involvement of FoxP3 in the development of Tregs was provided in patients suffering from IPEX, a rare and fatal human autoimmune disease. The emergence of Tregs and the role of FoxP3 as a critical player in the negative control of various normal and pathological immune responses holds great promise for the development of novel therapies for autoimmune diseases.
Synonyms	AIID; DIETER; IPEX; JM2; PIDX; XPID
Reference Data
Protein Families	Transcription Factors

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