PGRP1A (PGLYRP3) Mouse Monoclonal Antibody [Clone ID: 187C434]

Specifications

Product Data
Clone Name	187C434
Applications	FC, ICC/IF, WB
Recommend Dilution	Western Blot, Flow Cytometry: 1:10-1:1000, Flow (Cell Surface), Immunocytochemistry/ Immunofluorescence: 1:10-1:2000, Flow (Intracellular)
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 178-193 of human PGRP-1a.
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	peptidoglycan recognition protein 3
Database Link	NP_443123 Entrez Gene 114771 Human UniProt ID Q96LB9
Background	Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-1a (PGRP-3), and PGRP-1beta (PGRP-4)) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
Synonyms	PGLYRPIalpha; PGRP-Ialpha; PGRPIA
Note	Flow Cytometry (Cell Surface): see Uehara et al, (2005) Immunocytochemistry/Immunofluorescence: (see Uehara et al, 2005)
Reference Data
Protein Families	Druggable Genome

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