PGRP1A (PGLYRP3) Mouse Monoclonal Antibody [Clone ID: 187C434]
CAT#: TA336467
Mouse Monoclonal PGRP1A Antibody (187C434)
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CNY 4,897.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 9,998.00
Specifications
Product Data | |
Clone Name | 187C434 |
Applications | FC, ICC/IF, WB |
Recommend Dilution | Western Blot, Flow Cytometry: 1:10-1:1000, Flow (Cell Surface), Immunocytochemistry/ Immunofluorescence: 1:10-1:2000, Flow (Intracellular) |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 178-193 of human PGRP-1a. |
Formulation | Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Ascites |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | peptidoglycan recognition protein 3 |
Database Link | |
Background | Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-1a (PGRP-3), and PGRP-1beta (PGRP-4)) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood. PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain. |
Synonyms | PGLYRPIalpha; PGRP-Ialpha; PGRPIA |
Note | Flow Cytometry (Cell Surface): see Uehara et al, (2005) Immunocytochemistry/Immunofluorescence: (see Uehara et al, 2005) |
Reference Data | |
Protein Families | Druggable Genome |
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