IL23 Receptor (IL23R) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, Simple Western, WB
Recommend Dilution	Flow (Cell Surface), Immunohistochemistry-Paraffin: 5-10 ug/ml, Simple Western: 1:10, Flow Cytometry: 1:10-1:1000, Immunohistochemistry: 5-10 ug/ml, Western Blot: 0.5-1.0 ug/ml
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide located at amino acids 439-455 (EIFIPEHKPTDYKKENT) of human IL-23R (NP_653302).
Formulation	PBS with 0.09% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	72 kDa
Gene Name	interleukin 23 receptor
Database Link	NP_653302 Entrez Gene 209590 MouseEntrez Gene 149233 Human UniProt ID Q5VWK5
Background	IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23R, which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.
Synonyms	interleukin 23 receptor; OTTHUMP00000010660
Note	Based on immunogen sequence, this antibody will recognize the 629 amino acid (~68 KDa) , 390 AA (~42 KDa) and 227 AA (~26 KDa) forms of human IL-23R. Flow (Cell Surface): See Kortylweski et al, 2009 for details. Use in Flow cell surface reported in scientific literature (PMID 24358364)
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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