GATA4 Mouse Monoclonal Antibody [Clone ID: 6H10]

Specifications

Product Data
Clone Name	6H10
Applications	ELISA, WB
Recommend Dilution	Western Blot: 1:500-1:2000, ELISA: 1:10000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human GATA4 expressed in E. coli. [UniProt# P43694]
Formulation	Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ascites
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	GATA binding protein 4
Database Link	NP_002043 Entrez Gene 14463 MouseEntrez Gene 54254 RatEntrez Gene 2626 Human UniProt ID P43694
Background	GATA4, also known as GATA binding protein 4, is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
Synonyms	ASD2; TACHD; TOF; VSD1
Note	This GATA4 (6H10) antibody is useful for Western blot and ELISA.
Reference Data
Protein Families	Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

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