ABCG2 Mouse Monoclonal Antibody [Clone ID: 3G8]

Specifications

Product Data
Clone Name	3G8
Applications	ELISA, FC, ICC/IF, IHC, WB
Recommend Dilution	Flow Cytometry: 1:200-1:400, ELISA: 1:10000, Immunohistochemistry: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:200-1:1000, Western Blot: 1:500-1:2000, Immunohistochemistry-Paraffin: 1:200-1:1000
Reactivity	Human, Mouse, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human ABCG2 expressed in E. coli. [UniProt# Q9UNQ0]
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60-70 kDa
Gene Name	ATP binding cassette subfamily G member 2 (Junior blood group)
Database Link	NP_004818 Entrez Gene 26357 MouseEntrez Gene 9429 Human UniProt ID Q9UNQ0
Background	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
Synonyms	ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1
Note	This ABCG2 (3G8) antibody is useful for Western blot, Immunohistochemistry on paraffin-embedded sections, Immunocytochemistry/Immunofluorescence, Flow Cytometry and ELISA. In WB a dimer can be seen at 60-70 kDa representing ABCG2.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	ABC transporters

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