AREB6 (ZEB1) Mouse Monoclonal Antibody [Clone ID: 2A8A6]

Specifications

Product Data
Clone Name	2A8A6
Applications	FC, ICC/IF, IHC, WB
Recommend Dilution	Western Blot: 1: 500 - 1:2000, Flow Cytometry: 1:200 - 1:400, Immunocytochemistry/ Immunofluorescence: 1:100, Immunohistochemistry: 1:200 - 1:1000, Immunohistochemistry-Paraffin: 1:200 - 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partial recombinant human ZEB1 (between residues 800-1124) expressed in E. coli [Uniprot P37275]
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	zinc finger E-box binding homeobox 1
Database Link	NP_110378 Entrez Gene 6935 Human UniProt ID P37275
Background	ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.
Synonyms	AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
Reference Data
Protein Families	Transcription Factors

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.