IL22 Mouse Monoclonal Antibody [Clone ID: 8F11E2]

Specifications

Product Data
Clone Name	8F11E2
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 1 - 3 ug/mL, Immunohistochemistry-Paraffin: 5 ug/mL
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	MAPISSHCRL DkSNFQQPYI TNRTFMLAkE ASLADNNTDV RLIGEkLFHG VSMSERCYLM kQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQkLkDTV kkLGESGEIk AIGELDLLFM SLRNACI
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 22
Database Link	NP_065386 Entrez Gene 50616 Human UniProt ID Q9GZX6
Background	IL-22 is an inflammatory cytokine produced by so-called Th22 cells, especially, as well as Th17 cells. Activating through STAT3 signaling cascades, IL-22 is also expressed by numerous types of lymphocytes including LTi and LTi-like cells in the gut, Nk and T cells, and Langerhans cells which are APCs in the skin (1, 2). The protein is therefore expressed in effector cells of both the Innate and Adaptive Immune systems. Th22 cells, a subset of CD4 cells, preferentially express IL-22 and also express CCR6, CCR4 and CCR10--the latter two representing skin-homing receptors (3-5). Th22 cells do not express RORt or T-bet IL-17A or IFN (4). However, AHR appears to be a key priming transcription element for IL-22 as for IL-17A expression (5). IL-6 and TNF induce Th22 priming (1, 5). It also appears to have positive activities in wound healing and tissue repair since deficiencies in IL-22 in mouse models delay healing of intestinal biopsies (6). Other tissue repair activities have also been identified with the protein. Taken together, IL-22 is thought to be a key to maintaining a balance between inflammation and tolerance, or homeostasis, especially in skin and mucosal organs like the gut.
Synonyms	IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFa; TIFIL-23; zcyto18
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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