FEN1 Mouse Monoclonal Antibody [Clone ID: 7H8-F4-C11]

Specifications

Product Data
Clone Name	7H8-F4-C11
Applications	IF, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat, Hamster, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for FEN1 antibody: purified recombinant human FEN-1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	45 kDa
Gene Name	flap structure-specific endonuclease 1
Database Link	NP_004102 Entrez Gene 14156 MouseEntrez Gene 84490 RatEntrez Gene 2237 Human UniProt ID P39748
Background	The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions. [provided by RefSeq,Jul 2008]
Synonyms	FEN-1; MF1; RAD2
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Base excision repair, DNA replication, Non-homologous end-joining

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