DNMT1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA (1:100 ?? 1:1,000) ; Western blotting (1:500)
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-DNMT1 antibody: mouse DNMT1 (DNA (cytosine-5)-methyltransferase 1), using a KLH-conjugated synthetic peptide containing an amino acid sequence from the C-terminal part of the protein.
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	DNA (cytosine-5-)-methyltransferase 1
Database Link	NP_001124295 Entrez Gene 13433 Mouse UniProt ID P26358
Background	DNMT1 (UniProt/Swiss-Prot entry P26358) preferentially methylates CpG residues in hemimethylated DNA and is responsible for maintaining methylation patterns established in development. Inactivation of DNMT1 causes global demethylation and embryonic lethality. DNA methylation is coordinated with methylation of histones. Transcriptional repression by DNMT1 is mediated by direct interaction with HDAC2.
Synonyms	ADCADN; AIM; CXXC9; DNMT; HSN1E; m.HsaI; MCMT
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Cysteine and methionine metabolism, Metabolic pathways

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