H2BC5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Dot, ELISA
Recommend Dilution	ChIP (2ug/IP); ELISA (1:500); Dot blotting (1:20,000)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-H2B pan antibody: histone H2B using a KLH-conjugated synthetic peptide containing an unmodified sequence from the C-terminal part of the protein.
Concentration	lot specific
Purification	Affinity purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	histone cluster 1, H2bd
Database Link	NP_619790 Entrez Gene 3017 Human UniProt ID P62807
Background	Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histones play a central role in the regulation of transcription, DNA repair, DNA replication and chromosomal stability. These different functions are established via a complex set of post-translational modifications which either directly or indirectly alter chromatin structure and DNA accessibility to facilitate transcriptional activation or repression or other nuclear processes.
Synonyms	b; dJ221C16.6; H2B; H2B.1B; H2BFB; HIRIP2
Reference Data
Protein Pathways	Systemic lupus erythematosus

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