SETD1B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA (1:100 ?? 1:500) ; Western blotting (1:500)
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Setd1b antibody: mouse Setd1b (Set domain containing 1B), using a 3 KLH-conjugated synthetic peptides containing sequences from the central part of the protein.
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SET domain containing 1B
Database Link	NP_055863 Entrez Gene 23067 Human UniProt ID Q9UPS6
Background	SETD1B (UniProt/Swiss-Prot entry Q9UPS6) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1B shows a non-overlapping localization with SETD1A, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression.
Synonyms	KMT2G; Set1B
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Lysine degradation

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