Transglutaminase 2 (TGM2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-TGM2 Antibody: A synthesized peptide derived from human TGM2
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	77 kDa
Gene Name	transglutaminase 2
Database Link	NP_004604 Entrez Gene 21817 MouseEntrez Gene 7052 Human UniProt ID P21980
Background	TGM2 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation.
Synonyms	G-ALPHA-h; GNAH; HEL-S-45; TG2; TGC
Note	TGM2 Antibody detects endogenous levels of TGM2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease

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