NOTCH2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-NOTCH2 (Cleaved-Ala1734) Antibody: A synthesized peptide derived from human NOTCH2 (Cleaved-Ala1734)
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	110 kDa
Gene Name	notch 2
Database Link	NP_001186930 Entrez Gene 18129 MouseEntrez Gene 29492 RatEntrez Gene 4853 Human UniProt ID Q04721
Background	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Synonyms	AGS2; HJCYS; hN2
Note	NOTCH2 (Cleaved-Ala1734) Antibody detects endogenous levels of total NOTCH2 (Cleaved-Ala1734)
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Dorso-ventral axis formation, Notch signaling pathway

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