LYVE1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	FC, IF, PEP-ELISA, WB
Recommend Dilution	WB: 0.3- 1 ug/ml
Reactivity	Human, Mouse, Dog, Pig, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	The immunogen for Anti-MKRN1 (aa105-118) Antibody: Peptide with sequence C-RYEHSKPLKQEEAT, from the internet regoin of the protein sequence according to NP_038474.2; NP_001138597.1.
Formulation	Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lymphatic vessel endothelial hyaluronan receptor 1
Database Link	NP_006682 Entrez Gene 114332 MouseEntrez Gene 100855439 DogEntrez Gene 10894 Human UniProt ID Q9Y5Y7
Background	This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Synonyms	CRSBP-1; HAR; LYVE-1; XLKD1
Note	This antibody is expected to recognize both reported isoforms (NP_038474.2; NP_001138597.1).
Reference Data
Protein Families	Druggable Genome, Transmembrane

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