SRPX Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-5000 WB positive control: Human normal kidney and thyroid cancer tissue IHC: 25-100 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human SRPX
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	sushi repeat containing protein, X-linked
Database Link	NP_006298 Entrez Gene 8406 Human UniProt ID P78539
Background	SRPX gene also designated ETX1, resides within this region and is deleted in XLRP patients. There are at least two splice variants of SRPX, one of which contains a thirty amino acid signal peptide. Both variants contain three complement control protein domains, a hydrophobic region for membrane anchorage, and a cytoplasmic carboxy terminus. SRPX is expressed in retina and heart. SRPX is highly homologous to the drs (downregulated by v-src) human homolog, which suggests a role for SRPX as a tumor suppressor.
Synonyms	DRS; ETX1; HEL-S-83p; SRPX1
Reference Data

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